Treatment Recommendations

International consensus recommendations for management of New Onset Refractory Status Epilepticus (NORSE) incl. Febrile Infection-Related Epilepsy Syndrome (FIRES): Statements and Supporting Evidence, by Ronny Wickstrom,Olga Taraschenko,Robertino Dilena,Eric T. Payne,Nicola Specchio,Rima Nabbout,Sookyong Koh,Nicolas Gaspard,Lawrence J. Hirsch, The International NORSE Consensus Group, based upon 48 medical experts was published in Epilepsia, 23 August 2022 https://doi.org/10.1111/epi.17397

Families can read a short version of the article here: https://onlinelibrary.wiley.com/doi/10.1111/epi.17391

NORSE Diagnostic Evaluation

Disclaimer: This is a suggested guideline to investigate NORSE and FIRES.  It does not claim to be a complete list of tests to be done.  The NORSE Institute is grateful to its Medical Advisory Board and in particular to Drs. Nicolas Gaspard, Claudine Sculier, Lawrence J Hirsch, Sara Hocker, Zubeda Sheikh, Shivani Ghoshal, and Yashwanth Pulluru for their contributions. Additions to this checklist are welcome and can be sent via Contact page. (Updated: 2020)

Sample Treatment Algorithm 

Disclaimer: This is a sample treatment algorithm for generalized convulsive status epilepticus in adults and children posted with permission of Abdalla Ammar, PharmD; Lawrence J. Hirsch, MD; Emily J. Gilmore, MD; the Yale New Haven Hospital Department of Pharmacy Services; and the Yale University Dept of Neurology. The NORSE Institute is grateful to them for sharing this information. Comments are welcome. Send to Contact page. (Updated: 2020)